• In the current study we showed that known inhibitors of

  2024-02-01

  

  In the current study, we showed that known inhibitors of the F-ATPase and ionophores affect the growth of P. gingivalis and its plasma membrane ATPase, suggesting that the membrane ATPase can be a target for anti-periodontitis agents. We also identified stilbenoids that strongly inhibit the growth o

• Methotrexate This project was funded by the University of th

  2024-02-01

  

  This project was funded by the University of the Philippines Diliman through the Natural Sciences Research Institute with grant No. CHE-09-2-02. Introduction There is compelling evidence for an anti-inflammatory effect of 12- and 15-lipoxygenases through the generation of lipid mediators involve

• br Serine glycine and one carbon metabolism Altered serine

  2024-01-31

  

  Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer SecinH3 receptor [43]. The SSP branches from glycolysis at the point of 3-phosph

• Phytoremediation technology is defined as the use of

  2024-01-31

  

  Phytoremediation technology is defined as the use of plants to remove contaminants from soils or to render them harmless, and is regarded as a cost-effective, environmental-friendly method for reclaiming soils contaminated by toxic metals (Lasat, 2002, Mahar et al., 2016, Marrugo-Negrete et al., 201

• To reconstruct the amino acid sequence of

  2024-01-30

  

  To reconstruct the amino Senegenin sequence of an ancestral β subunit a molecular phylogeny is required, which is inferred from a β subunit sequence alignment. To build this alignment we searched the NCBI database for proteins similar in sequence to the human muscle-type β subunit precursor protein,

• Our analysis has devoted limited attention to

  2024-01-30

  

  Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost

• Moreover our present work suggests

  2024-01-30

  

  Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in Nucleozin sale activated with AXL receptor ligand. A role for AX

• br Acknowledgements We thank Dr Stefan Schulte

  2024-01-30

  

  Acknowledgements We thank Dr. Stefan Schulte-Merker and his group members at the Hubrecht Institute (Utrecht, the Netherlands) for their invaluable support of the zebrafish studies. Our work is supported by grants from the Dutch Cancer Society (KWF) and the Netherlands Organisation for Scientific

• The use of FTAI can overcome the negative impact

  2024-01-30

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable X-NeuNAc follicle. Pregnancy rates obtained with FTAI may be comparable or better than those obtained after

• Introduction Cardiovascular disease is the

  2024-01-30

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with Molidustat (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular r

• Our previous study showed that TRIM could target TSC TSC

  2024-01-30

  

  Our previous study showed that TRIM31 could target TSC1-TSC2 complex and contributed to the clinical cancer progression [6]. In this study, we showed that TRIM31 could directly target p53 for ubiquitous degradation and further mediated anoikis-resistance of HCC cells. To further clarify the role of

• A unique finding in this study

  2024-01-30

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic Cyclo(RGDyK) receptor for substrate, can regulate CREB phosphoryation in the context of

• br Effects of BCAAs on glucose metabolism Insulin plays

  2024-01-30

  

  Effects of BCAAs on glucose metabolism Insulin plays an exclusive role in regulation of glucose metabolism, and obesity and type 2 diabetes induce hyperinsulinemia due to insulin resistance. Plasma BCAA concentrations are increased by 14–20% in patients with hyperinsulinemia under overnight fasti

• There are human genes in the SLC A

  2024-01-29

  

  There are 12 human genes in the SLC5A family, and 6 of these are expressed in human heart (Table 2). Little is known about SGLT proteins in the heart. Zhou et al. [56] reported the presence of SGLT1 mRNA in the human heart. Researchers have found that levels of SGLT1 mRNA in heart are approximately

• br ABCA modulates intracellular sphingolipid

  2024-01-29

  

  ABCA2 modulates intracellular sphingolipid metabolism in the LE/LY Recycling of plasma membrane lipids that occurs by constitutive endocytosis and vesicularization of complex glycolipids, complex sphingolipids and cholesterol as well as free cholesterol liberated from LDL after receptor-mediated

15613 records 210/1041 page Previous Next First page 上5页 206207208209210 下5页 Last page