• Bufuralol Hydrochloride in Precision β-Adrenergic Modulat...

  2025-09-26

  Explore how Bufuralol hydrochloride, a non-selective β-adrenergic receptor antagonist, is transforming cardiovascular pharmacology research through mechanistic insights and integration with advanced human organoid models. Discover its unique potential in precision β-adrenergic modulation studies and next-generation pharmacokinetic platforms.

• ABT-263 (Navitoclax): Advancing Precision Apoptosis Resea...

  2025-09-25

  Explore how ABT-263 (Navitoclax), a potent Bcl-2 family inhibitor, is redefining apoptosis research in cancer biology. This article uniquely focuses on leveraging ABT-263 for dissecting apoptotic signaling dynamics, mitochondrial priming, and resistance mechanisms, offering advanced insight beyond standard applications.

• Y-27632 Dihydrochloride: Advanced Modulation of ROCK Sign...

  2025-09-24

  Explore the multifaceted applications of Y-27632 dihydrochloride, a selective ROCK inhibitor, in modulating the Rho/ROCK signaling pathway for stem cell viability enhancement and suppression of tumor invasion. This in-depth review uniquely examines emerging intersections with Paneth cell biology and ISC aging.

• Bufuralol Hydrochloride in Human Intestinal Organoid-Base...

  2025-09-23

  This article explores the application of Bufuralol hydrochloride, a non-selective β-adrenergic receptor antagonist, in advanced cardiovascular pharmacology and pharmacokinetic studies using human intestinal organoids. It highlights the unique intersection of β-adrenergic modulation research and innovative in vitro modeling for drug metabolism.

• For the time being fluorescent in situ hybridization FISH

  2025-03-03

  

  For the time being, fluorescent in situ hybridization (FISH) remains the ‘gold standard’ for ALK rearrangements diagnosis but immunohistochemistry has become a widely used pre-screening tool and the FDA recently approved the Ventana ALK (D5F3) CDx Assay (Ventana Medical Systems, Tucson, AZ) as a com

• br Experimental br Acknowledgment br Introduction The NADPH

  2025-03-03

  

  Experimental Acknowledgment Introduction The NADPH-dependent reduction of d-glucose catalyzed by aldose reductase (E.C.1.1.1.21) (AR) is considered as one of the phenomena leading to the onset of long term diabetic complications [as review see: [1], [2]. In fact, the reduction of the sugar,

• Targeted disruption of the Akt gene

  2025-03-03

  

  Targeted disruption of the Akt1 gene in mice induces a growth retardation phenotype [4,19]. Akt2 KO mice reveal mild growth retardation and insulin resistance [4,20,21]. Akt1/2 double KO (DKO) mice display severe growth deficiency and die shortly after birth. These mice exhibit impaired bone and ski

• br Roles for GMF in Endocytic Traffic In addition to

  2025-03-03

  

  Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune cy5 42, 51. Vinculin, a central component of focal adhesions that anchors cells to their

• The major strength of this

  2025-03-03

  

  The major strength of this study is the large sample size which increases the statistical power to detect the likely subtle differences in peripheral methylation observed in psychiatric disorders (Olsson et al., 2010). Larger studies help provide more robust estimates of true associations, as small

• PMX 205 Despite functional studies demonstrating the

  2025-03-03

  

  Despite functional studies demonstrating the role of 5-HT in ureteral contractility, the source of endogenous 5-HT in the ureter is unclear. Since 5-HT-containing enterochromaffin cells, which are present in the gastrointestinal tract, could not be found in the ureter (Nocito et al., 2007, Ripoche,

• Prostate cancer is the second leading cause of cancer relate

  2025-03-03

  

  Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate can

• We next sought to determine the kinase

  2025-03-01

  

  We next sought to determine the kinase responsible for IR-induced phosphorylation of 53BP1. Because the sites under investigation all lie in a consensus sequence for ATM, ATR and DNA-PK, that are all activated by IR, the involvement of each of these kinases was investigated. Preincubation of Oxonic

• br Activity and expression of

  2025-03-01

  

  Activity and expression of aromatase in the hippocampus The brain, like the adrenals, gonads and the placenta, is a steroidogenic organ. This paradigm emerged from studies carried out as early as the 1980s by Baulieu and co-workers; these studies showed that steroids such as pregnenolone and dehy

• Apelin APJ triggers a variety of cellular signaling pathways

  2025-03-01

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

• On the other hand oxygen concentration in

  2025-03-01

  

  On the other hand, oxygen concentration in tumor tissue also depends on its consumption rate by tumor cells, which decrease will also lead to alleviation of hypoxia. This fact is not taken into account in the majority of studies on the topic, although it is well-known that antiangiogenic therapy doe

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